Let's talk about what the TL would be if the USSR started to collapse in 1941. I'm assuming Leningrad, Moscow, and Rostov fall in 1941 and Sevastopol probably does too. In 1942 the USSR is in collapse and organized resistance is falling apart as the Red Army fights it out amongst itself for power and probably with the NKVD. The Axis roll over Stalingrad and into the Caucasus with minor losses, securing Maykop more or less intact, same with the ports on the Black Sea and pipelines, enabling them to start extracting oil. They probably are able to reach and secure Grozny, its oil, and the pipeline to Tuapse. In the meantime to prevent the Germans from securing Baku and Tiblisi the Wallies bomb them, but cannot get at Maykop and Grozny. Oil is exported via the Black Sea to Romania for refining and gives the Axis all the oil it needs for the war effort. Pilot training isn't gutted in 1942 then and can be stepped up.
Let's say Japan still attacks the US, just ITTL the Kwantung army attacks Russia in the Far East once the USSR falls apart.
In 1942 there is significantly more airpower for the Mediterranean and in France due to the Soviets pretty much collapsing in 1941. There is more aluminum available to the Axis from the USSR when the Volkov/Tikhvin area falls. Finland secures all of Karelia, all the German mountain troops used in the north are either sent to the Caucasus, Norway, or Yugoslavia. The Battle of the Atlantic plays out roughly the same ITTL. The Baltic is secured. Malta falls in August 1942 when Operation Pedestal fails to supply Malta due to greater German airpower in the Mediterranean and extra fuel for the Italian navy allowing major units to sortie against the convoy. Egypt does not, that front plays out the same due to insurmountable logistics issues. Dieppe perhaps fails even worse with greater German army and air power in France in August 1942.
Operation Torch still happens, perhaps sooner without the need for LL to the USSR. Thanks to improved supply due to the fall of Malta and more trucks and replacements of everything Rommel is able to rally and check Monty around Benghazi while a new Panzer army in Tunisia checks the Torch landing and secures more turf than IOTL due to more men being available and better supply. North Africa is a more active front into 1943, perhaps with Kasserine being an Axis victory due to more men, equipment, and supply. Not sure how that plays out in the long run, but its a meat grinder for the Axis pretty much no matter what, even if all the Tigers available end up there and there is plenty of supply and aircraft. Probably no Sicily invasion until 1944 at the earliest.
More Axis production is based on air defense, meaning more AAA and fighters. Probably greater attempts at night bombing against Britain too. Without the East Front France probably doesn't happen in 1944, so the V-1 problem continues throughout 1944 into 1945, with lots of bombing effort aimed at stopping it. Without a foothold in France the German radar screen is not breeched and Allied fighters cannot do their OTL damage from continental bases. Oil production, even if attacked from Britain, cannot be destroyed like IOTL due to Caucasian oil via the Black Sea being untouchable and without Italian bases, so it Romania effectively. The Yugoslav partisan problem is probably quashed in 1943 without an active Eastern front. The Wallies are pretty wary about an invasion of the continent given how many more German/Italian troops are around from 1943 on. Sicily is probably too tough a nut to crack, so Sardinia probably gets invaded first to set up a bombing base against Italy. Depending on how quickly North Africa falls that may not be until 1943 or even delayed into 1944. In the end Africa will wear down the Axis pretty badly, while the Wallies suffer worse overall losses than IOTL between 1942-44.
I don't think Operation Vegetation would be approved, probably too much risk of blow back if the Germans collect spores and use them against Britain. It would also cause inhuman suffering among civilians, not just enemy ones if it spreads and once the Germans replace their cattle losses from occupied populations in the West.
The question is whether the LW could be beat down enough in 1944-45 to enable Normandy in 1945 or whether they wait for the bomb. Likely the Germans evacuate industry and population East out of range of bombing, while the Allies bomb transport heavily to prevent that material from moving West to France. The Axis even with resources from the East and careful husbanding of aircraft, plus all the extra AAA, would likely still be suffering quite heavily, even if they are able to inflict much more heavy combat losses. The big issue in 1945 is that without a foothold on the continent and with greater mineral resources the Germans will have their jet fighters en masse with more reliable engines thanks to the nickel from Finland and the Donbas. Turkey and Spain won't stop selling to the Axis in 1944 ITTL due to how much better they are doing and how much of a threat they still are, so that means chromium and tungsten still flow even with Allied bidding wars driving up prices. Without the large human losses in the East from 1941 on German production likely keeps German labor for the more sensitive production like aircraft, engines, and whatnot, preventing the problems of sabotage. By 1944 the German electronics industry was putting out cribbed cavity magnetron based radar of British design captured from shot down bombers and without the collapsing ground situation and somewhat better air situation that will be a big problem for the Allies in 1945 as much more of that is around and improving FLAK and night fighter defenses. By day though P-51 spamming and by night Mosquito night fighter intruders will be major problems from 1944 on, not sure how the Axis can handle that given their production disadvantage. Even with Italy still onside in 1944-45, it will be a mess due to bombing once Sardinia is a bomber base.
At what point is there too many losses for British and US publics? When nukes come online do they get first used in Asia or Europe? Would knocking out Japan be a priority or possible without the USSR helping on the mainland?